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Persistent fibrous myositis with circulating IgM antibody: a clinical and pathological study of a juvenile patient.
A case of persistent fibromyositis associated with an IgM-containing circulating antibody is reported. The patient, a 13-year-old girl, presented with a rapidly progressive symmetrical weakness and wasting of the muscles of the limbs, the neck, and the face. Nerve conduction studies were performed. Antinuclear antibody, anti-tissue antigens antibody, and anti-DNA antibody were all negative. Pathological findings in muscle biopsy showed a lymphocytic myositis. Immunohistochemical examination showed scattered lymphocytes and plasma cells infiltrating the endomysium and perimysium. Immunofluorescence studies revealed IgM-containing circulating antibodies in the patient’s serum. The patient’s IgM antibodies were highly cross-reactive against dystonin, plectin, agrin, and titin. This is the first report in which IgM antibody to a membrane protein has been detected in serum of a patient with fibromyositis.The invention relates to a device for producing gaseous mixtures which are to be supercharged with a mixture of fuel gases, where several gas-combustion burners are used.
A device of this kind is known, for example, from DE 21 38 058 A1. In this connection, burners for producing gaseous mixtures are provided which are supplied with a fuel gas and air. These burners are arranged on several surrounding sides of the free central space of the housing of the plant.Role of Ras in EGFR-induced cell proliferation.
Activated EGFR (EGFR(Tyr)1068) was stimulated by EGF or by expression of the activated human EGFR. The specific association of EGFR with Ras(G12V) was confirmed in intact cells by co-immunoprecipitation and immunofluorescence, and the activated Ras was associated with the EGFR in the same anti-EGFR precipitates. Activated EG