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Atomically updating a massive index in SQLite

I have a sqlite database that is over 200GB. The table in question has over 10 million records. The database has a unique index on a field (has never been disabled). I need to add a new column to the index, and I am running into huge speed issues.
I tried to update the records in chunks, but this works terribly as the index is over 10 million records. Is there any way to update the index atomically?

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A major cause of the problem is that SQLite’s unique constraints are not enforced when re-indexing, so your index is not atomically updated as you need it to be. This

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